اثر هشت هفته تمرین مقاومتی بر سطوح BDNF و عملکرد حافظه زنان میانسال مبتلا به سندروم متابولیک

نوع مقاله : علمی - پژوهشی

نویسندگان

1 استادیار گروه تربیت بدنی و علوم ورزشی دانشگاه سمنان

2 کارشناسی ارشد تربیت بدنی و علوم ورزشی دانشگاه سمنان

چکیده

مقدمه و هدف: هدف از تحقیق حاضر بررسی اثر هشت هفته تمرین مقاومتی بر سطوح BDNF و عملکرد حافظه زنان میانسال مبتلا به سندروم متابولیک بود. روش شناسی: 22 زن داوطلب میانسال مبتلا به سندروم متابولیک به صورت نمونه‌گیری در دسترس، گزینش شدند و به طور تصادفی به دو گروه تمرین (تعداد=12، 14/5 ± 08/43 سال، 16/7 ± 13/74 کیلوگرم) و گروه کنترل (تعداد=10، 53/4 ± 9/39 سال، 61/11 ± 23/82 کیلوگرم) تقسیم شدند. آزمودنی‌های گروه تمرین به مدت هشت هفته و سه روز در هر هفته به تمرین مقاومتی پرداختند. تمرین شامل سه نوبت هشت تا ده تکراری (75% -80% 1RM) با در نظر گرفتن اصل اضافه بار بود. در مراحل پیش‌ازمون و پایان تمرین، آزمون‌های عملکرد حافظه کوتاه‌مدت و میان­مدت و بلندمدت و همچنین خون­گیری انجام شد. داده‌ها با استفاده از آزمون‌های تی مستقل، تی وابسته و آنالیز واریانس با اندازه‌گیری مکرر 2×2 با سطح معنی داری 05/0 P≤تجزیه و تحلیل شدند. یافته‌ها: تغییر معنی‌داری در سطوح BDNF و حافظه میان مدت در دو گروه تمرین و کنترل مشاهده نشد (05/0P≥). نتایج آزمون  tوابسته افزایش معنی‌داری در گروه تمرین در حافظه کوتاه‌مدت و بلندمدت نشان داد (05/0P≤)، اما پس از بررسی اثر تعاملی تمرین تغییرات معنی‌داری مشاهده نشد(05/0P≥). نتیجه گیری: با وجود اینکه BDNF به عنوان یک متابوتروفین، میانجی اثرات ورزش بر عملکرد شناختی شناخته شده است؛ اما هشت هفته تمرین مقاومتی نمی‌تواند اثر مطلوبی بر افزایش BDNF و عملکرد حافظه در زنان میانسال مبتلا به سندروم متابولیک داشته باشد. 

کلیدواژه‌ها


  1. Allan, R., et al. (2013). "Exercise and Bdnf Production as a Future Treatment for Alzheimer’s Disease."
  2. Okosun IS, Annor F, Esuneh F, Okoegwale EE.
  3. (2013) Metabolic syndrome and impaired healthrelated
  4. quality of life and in non-Hispanic White,
  5. non-Hispanic Blacks and Mexican-American
  6. Adults. Diabetes & Metabolic Syndrome:
  7. Clinical Research & Reviews.7(3):154-60.
  8. Raffaitin C, Gin H, Empana J-P, Helmer C, Berr
  9. C, Tzourio C, et al.(2009). Metabolic Syndrome
  10. and Risk for Incident Alzheimer's Disease or
  11. Vascular Dementia The Three-City Study.
  12. Diabetes care.32(1):169-74.
  13. Baker LD, Cross DJ, Minoshima S, Belongia D,
  14. Watson GS, Craft S. (2011) Insulin resistance
  15. and Alzheimer-like reductions in regional
  16. cerebral glucose metabolism for cognitively
  17. normal adults with prediabetes or early type 2
  18. diabetes. Archives of neurology.68(1):51-7.
  19. Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi
  20. K, Matsui Y, et al. (2010). Insulin resistance is
  21. associated with the pathology of Alzheimer disease
  22. The Hisayama Study. Neurology.75(9):764-70.
  23. Schrijvers EM, Witteman J, Sijbrands E, Hofman
  24. A, Koudstaal P, Breteler M.( 2010). Insulin
  25. metabolism and the risk of Alzheimer disease
  26. The Rotterdam Study. Neurology.75(22):1982-7.
  27. Dik MG, Jonker C, Comijs HC, Deeg DJ, Kok
  28. A, Yaffe K, et al. (2007) Contribution of
  29. metabolic syndrome components to cognition in
  30. older individuals. Diabetes care.30(10):2655-60.
  31. Yaffe K. (2007) Metabolic syndrome and
  32. cognitive disorders: is the sum greater than its
  33. parts? Alzheimer Disease & Associated
  34. Disorders.21(2):167-71.
  35. Xu B, Goulding EH, Zang K, Cepoi D, Cone
  36. RD, Jones KR, et al. (2003) Brain-derived
  37. neurotrophic factor regulates energy balance
  38. downstream of melanocortin-4 receptor. Nature
  39. neuroscience. 6(7):736-42.
  40. Nonomura T, Tsuchida A, Ono-Kishino M,
  41. Nakagawa T, Taiji M, Noguchia H. (2001)
  42. Brain-derived neurotrophic factor regulates
  43. energy expenditure through the central nervous
  44. system in obese diabetic mice. Experimental
  45. Diabetes Research.2(3):201-9.
  46. Tsuchida A, Nonomura T, Nakagawa T, Itakura
  47. Y, Ono‐Kishino M, Yamanaka M, et al. (2002)
  48. Brain‐derived neurotrophic factor ameliorates
  49. lipid metabolism in diabetic mice. Diabetes,
  50. Obesity and Metabolism. 4(4):262-9.
  51. Correia PR, Scorza FA, da Silva SG, Pansani A,
  52. Toscano-Silva M, de Almeida AC, et al. (2011)
  53. Increased basal plasma brain-derived neurotrophic
  54. factor levels in sprint runners. Neuroscience
  55. bulletin. 27(5):325-9.
  56. Yamada K, Nabeshima T. (2003) Brain-derived
  57. neurotrophic factor/TrkB signaling in memory
  58. processes. Journal of pharmacological sciences.
  59. (4):267-70.
  60. Benraiss A, Chmielnicki E, Lerner K, Roh D,
  61. Goldman SA. (2001) Adenoviral brain-derived
  62. neurotrophic factor induces both neostriatal and
  63. olfactory neuronal recruitment from endogenous
  64. progenitor cells in the adult forebrain. The
  65. Journal of Neuroscience. 21(17):6718-31.
  66. Zuccato C, Cattaneo E. (2009) Brain-derived
  67. ابراهیمی و همکاران
  68. neurotrophic factor in neurodegenerative
  69. diseases. Nature Reviews Neurology.5(6):311-
  70. Noble EE, Billington CJ, Kotz CM, Wang C.
  71. (2011) The lighter side of BDNF. American
  72. Journal of Physiology-Regulatory, Integrative
  73. and Comparative Physiology. 300(5):R1053-
  74. R69.
  75. Knaepen K, Goekint M, Heyman EM, Meeusen
  76. R. (2010) Neuroplasticity - exercise-induced
  77. response of peripheral brain-derived
  78. neurotrophic factor: a systematic review of
  79. experimental studies in human subjects. Sports
  80. medicine (Auckland, NZ). 40(9):765-801.
  81. Lommatzsch M, Zingler D, Schuhbaeck K,
  82. Schloetcke K, Zingler C, Schuff-Werner P, et al.
  83. (2005) The impact of age, weight and gender on
  84. BDNF levels in human platelets and plasma.
  85. Neurobiology of aging.26(1):115-23.
  86. Allan R, Collino T, Oluwarounke H. (2013)
  87. Exercise and Bdnf Production as a Future
  88. Treatment for Alzheimer’s Disease.
  89. Goekint M, Heyman E, Roelands B, Njemini R,
  90. Bautmans I, Mets T, et al. (2008). No influence
  91. of noradrenaline manipulation on acute exerciseinduced
  92. increase of brain-derived neurotrophic
  93. factor. Med Sci Sports Exerc.40(11):1990-6.
  94. Zoladz J, Pilc A, Majerczak J, Grandys M,
  95. Zapart-Bukowska J, Duda K. (2008) Endurance
  96. training increases plasma brain-derived
  97. neurotrophic factor concentration in young
  98. healthy men. J Physiol Pharmacol. 59(Suppl
  99. :119-32.
  100. Vega SR, Strüder HK, Wahrmann BV, Schmidt
  101. A, Bloch W, Hollmann W. (2006) Acute BDNF
  102. and cortisol response to low intensity exercise
  103. and following ramp incremental exercise to
  104. exhaustion in humans. Brain research.
  105. (1):59-65.
  106. Ferris LT, Williams JS, Shen C-L. (2007) The
  107. effect of acute exercise on serum brain-derived
  108. neurotrophic factor levels and cognitive function.
  109. Medicine and science in sports and
  110. exercise.39(4):728-34.
  111. Tang SW, Chu E, Hui T, Helmeste D, Law C.(
  112. . Influence of exercise on serum brainderived
  113. neurotrophic factor concentrations in
  114. healthy human subjects. Neuroscience letters.
  115. (1):62-5.
  116. Rasmussen P, Brassard P, Adser H, Pedersen
  117. MV, Leick L, Hart E, et al. (2009) Evidence for a
  118. release of brain‐derived neurotrophic factor from
  119. the brain during exercise. Experimental
  120. physiology. 94(10):1062-9.
  121. Winter B, Breitenstein C, Mooren FC, Voelker
  122. K, Fobker M, Lechtermann A, et al. (2007) High
  123. impact running improves learning. Neurobiology
  124. of learning and memory. 87(4):597-609.
  125. Yarrow JF, White LJ, McCoy SC, Borst SE.
  126. (2010). Training augments resistance exercise
  127. induced elevation of circulating brain derived
  128. neurotrophic factor (BDNF). Neuroscience
  129. letters. 479(2):161-5.
  130. Schiffer T, Schulte S, Hollmann W, Bloch W,
  131. Struder HK. (2009). Effects of strength and
  132. endurance training on brain-derived neurotrophic
  133. factor and insulin-like growth factor 1 in
  134. humans. Hormone and metabolic research =
  135. Hormon- und Stoffwechselforschung =
  136. Hormones et metabolisme. 41(3):250-4.
  137. Schulz KH, Gold SM, Witte J, Bartsch K, Lang
  138. UE, Hellweg R, et al. (2004). Impact of aerobic
  139. training on immune-endocrine parameters,
  140. neurotrophic factors, quality of life and
  141. coordinative function in multiple sclerosis.
  142. Journal of the neurological sciences. 225(1-
  143. :11-8.
  144. Castellano V, White LJ. (2008). Serum brainderived
  145. neurotrophic factor response to aerobic
  146. exercise in multiple sclerosis. Journal of the
  147. neurological sciences.269(1):85-91.
  148. Correia PR, Pansani A, Machado F, Andrade M,
  149. Silva AC, Scorza FA, et al. (2010). Acute
  150. strength exercise and the involvement of small or
  151. large muscle mass on plasma brain-derived
  152. neurotrophic factor levels. Clinics (Sao Paulo,
  153. Brazil). 65(11):1123-6.
  154. Goekint M, De Pauw K, Roelands B, Njemini R,
  155. Bautmans I, Mets T, et al. (2010) Strength
  156. training does not influence serum brain-derived
  157. neurotrophic factor. European journal of applied
  158. physiology. 110(2):285-93.
  159. Cao L, Lin E-JD, Cahill MC, Wang C, Liu X,
  160. During MJ. (2009). Molecular therapy of obesity
  161. and diabetes by a physiological autoregulatory
  162. approach. Nature medicine. 15(4):447-54.
  163. Wilson RS, Schneider JA, Bienias JL, Evans
  164. DA, Bennett DA. (2003). Parkinsonianlike signs
  165. and risk of incident Alzheimer disease in older
  166. persons. Archives of neurology. 60(4):539-44.
  167. Smith PJ, Blumenthal JA, Hoffman BM, Cooper
  168. H, Strauman TA, Welsh-Bohmer K, et al.( 2010).
  169. Aerobic exercise and neurocognitive performance:
  170. a meta-analytic review of randomized controlled
  171. trials. Psychosomatic medicine. 72(3):239.
  172. Raschetti R, Albanese E, Vanacore N, Maggini
  173. M. (2007). Cholinesterase inhibitors in mild
  174. cognitive impairment: a systematic review of
  175. randomised trials. PLoS medicine. 4(11):e338.
  176. Lachman ME, Neupert SD, Bertrand R, Jette
  177. و عملکرد حافظه زنان میانسال ... 1323 BDNF اثر هشت هفته تمرین مقاومتی بر سطوح
  178. AM. (2006). The effects of strength training on
  179. memory in older adults. Journal of aging and
  180. physical activity. 14(1):59-73.
  181. Leff P, Romo H, Matus M, Hernandez A, Calva
  182. JC, Acevedo R, et al. (2002). Understanding the
  183. neurobiological mechanisms of learning and
  184. memory: memory systems of the brain, longterm
  185. potentiation and synaptic plasticity. Part III
  186. B. Salud Mental. 25(3):64-76.
  187. Expert Panel on Detection E. (2001). Executive
  188. summary of the third report of the National
  189. Cholesterol Education Program (NCEP) expert
  190. panel on Detection, Evaluation, and Treatment of
  191. high blood cholesterol in adults (Adult Treatment
  192. Panel III). Jama. 285(19):2486.
  193. Brzycki M. (1993). Strength testing—predicting
  194. a one-rep max from reps-to-fatigue. Journal of
  195. Physical Education, Recreation & Dance.
  196. (1):88-90.
  197. Conceicao MS, Bonganha V, Vechin FC, de
  198. Barros Berton RP, Lixandrão ME, Nogueira
  199. FRD, et al. (2013). Sixteen weeks of resistance
  200. training can decrease the risk of metabolic
  201. syndrome in healthy postmenopausal women.
  202. Clinical interventions in aging. 8:1221.
  203. Stone MH, O'Bryant H, Garhammer J, McMillan
  204. J, Rozenek R.( 1982). A Theoretical Model of
  205. Strength Training. Strength & Conditioning
  206. Journal. 4(4):36-9.
  207. Brown LE, Weir JP.( 2001). Asep Procedures
  208. Recommendation I: Accurate Assessment of
  209. Muscular Strength and Power. Professionalization
  210. of Exercise Physiology. 4(11).
  211. Marnat G. (2005). Psychological Evaluation
  212. Guidelines for clinical psychologists, counselors
  213. and psychiatrists. Translation by Mohammad
  214. Hassan Pasha Sharifi and Mohammad Reza
  215. Nikkhou Tehran: Growth Publication(Persian).
  216. Deschenes MR, Kraemer WJ. (2002).
  217. Performance and physiologic adaptations to
  218. resistance training. American Journal of Physical
  219. Medicine & Rehabilitation. 81(11):S3-S16.
  220. Levinger I, Goodman C, Matthews V, Hare DL,
  221. Jerums G, Garnham A, et al. (2008). BDNF,
  222. metabolic risk factors, and resistance training in
  223. middle-aged individuals. Med Sci Sports Exerc.
  224. (3):535-41.
  225. Coelho F, Pereira D, Lustosa L, Silva J, Dias J,
  226. Dias R, et al. (2012) Physical therapy intervention
  227. (PTI) increases plasma brain-derived neurotrophic
  228. factor (BDNF) levels in non-frail and pre-frail
  229. elderly women. Archives of gerontology and
  230. geriatrics. 54(3):415-20.
  231. Matthews V, Åström M-B, Chan M, Bruce C,
  232. Krabbe K, Prelovsek O, et al. (2009).Brainderived
  233. neurotrophic factor is produced by
  234. skeletal muscle cells in response to contraction
  235. and enhances fat oxidation via activation of
  236. AMP-activated protein kinase. Diabetologia.
  237. (7):1409-18.
  238. Parnow A, Karimi I, Hosseini SA. (2015). Effect
  239. of Resistance Training on Plasma Brain Derived
  240. Neurotrophic Factor Levels in Rats. Journal of
  241. Knowledge & Health; VOL 10, NO 3:2015.
  242. Babaei P, damirchi a, Azali Alamdari K. (2013).
  243. Effects of Endurance Training and Detraining on
  244. Serum BDNF and Memory Performance in
  245. Middle Aged Males with Metabolic Syndrome.
  246. Iranian Journal of Endocrinology and
  247. Metabolism. 15(2):132-42.
  248. Suwa M, Kishimoto H, Nofuji Y, Nakano H,
  249. Sasaki H, Radak Z, et al. (2006). Serum brainderived
  250. neurotrophic factor level is increased and
  251. associated with obesity in newly diagnosed
  252. female patients with type 2 diabetes mellitus.
  253. Metabolism. 55(7):852-7.
  254. Ramsbottom R, Currie J, Gilder M. (2010).
  255. Relationships between components of physical
  256. activity, cardiorespiratory fitness, cardiac
  257. autonomic health, and brain-derived neurotrophic
  258. factor. Journal of sports sciences. 28(8):843-9.
  259. Golden E, Emiliano A, Maudsley S, Windham
  260. BG, Carlson OD, Egan JM, et al. (2010).
  261. Circulating brain-derived neurotrophic factor and
  262. indices of metabolic and cardiovascular health:
  263. data from the Baltimore Longitudinal Study of
  264. Aging. PloS one. 5(4):e10099.
  265. Arentoft A, Sweat V, Starr V, Oliver S,
  266. Hassenstab J, Bruehl H, et al. (2009). Plasma
  267. BDNF is reduced among middle-aged and
  268. elderly women with impaired insulin function:
  269. evidence of a compensatory mechanism. Brain
  270. and cognition. 71(2):147-52.
  271. Chang Y-K, Pan C-Y, Chen F-T, Tsai C-L,
  272. Huang C-C. (2012). Effect of resistance exercise
  273. training on cognitive function in healthy older
  274. adults: a review. Journal of aging and physical
  275. activity. 20(4):497-517.
  276. Colcombe S, Kramer AF. (2003). Fitness effects
  277. on the cognitive function of older adults a metaanalytic
  278. study. Psychological science. 14(2):125-
  279. Solfrizzi V, Scafato E, Capurso C, D’Introno A,
  280. Colacicco AM, Frisardi V, et al. (2011).
  281. Metabolic syndrome, mild cognitive impairment,
  282. and progression to dementia. The Italian
  283. Longitudinal Study on Aging. Neurobiology of
  284. aging. 32(11):1932-41.
  285. Komulainen P, Lakka TA, Kivipelto M, Hassinen
  286. M, Helkala E-L, Haapala I, et al. (2007). Metabolic
  287. ابراهیمی و همکاران
  288. syndrome and cognitive function: a populationbased
  289. follow-up study in elderly women. Dementia
  290. and geriatric cognitive disorders. 23(1):29-34.
  291. Yates KF, Sweat V, Yau PL, Turchiano MM,
  292. Convit A. (2012). Impact of metabolic syndrome
  293. on cognition and brain a selected review of the
  294. literature. Arteriosclerosis, thrombosis, and
  295. vascular biology. 32(9):2060-7.
  296. Cassilhas RC, Viana VA, Grassmann V, Santos
  297. RT, Santos RF, Tufik S, et al. (2007). The impact
  298. of resistance exercise on the cognitive function
  299. of the elderly. Medicine and science in sports
  300. and exercise. 39(8):1401.
  301. Tsutsumi T, Don BM, Zaichkowsky LD,
  302. Delizonna LL. (1997). Physical fitness and
  303. psychological benefits of strength training in
  304. community dwelling older adults. Applied
  305. human science. 16(6):257-66.
  306. Kramer AF, Erickson KI. (2007). Capitalizing on
  307. cortical plasticity: influence of physical activity
  308. on cognition and brain function. Trends in
  309. cognitive sciences. 11(8):342-8.
  310. Cotman CW, Berchtold NC. (2002). Exercise: a
  311. behavioral intervention to enhance brain health
  312. and plasticity. Trends in neurosciences. 25(6):
  313. -301.
  • تاریخ دریافت: 23 شهریور 1395
  • تاریخ بازنگری: 10 اسفند 1402
  • تاریخ پذیرش: 11 دی 1399
  • تاریخ اولین انتشار: 11 دی 1399
  • تاریخ انتشار: 01 آذر 1395