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اثر یک دوره تمرین مقاومتی برسطوح سرمی پپتید شبه گلوکاگون-1، دی پپتیدیل پپتیداز-4 و مقاومت انسولین در مردان چاق

نوع مقاله : علمی - پژوهشی

نویسندگان

1 گروه تربیت بدنی و علوم ورزشی واحد آیت اﷲ آملی، دانشگاه آزاد اسلامی، آمل، ایران

2 گروه تربیت بدنی و علوم ورزشی واحد یادگار امام خمینی ( ره ) شهر رى، دانشگاه آزاد اسلامی تهران، ایران

3 دانشجوى دکترى بیوشیمی و متابولیسم ورزشی گروه تربیت بدنی و علوم ورزشی واحد تهران مرکز، دانشگاه آزاد اسلامی، تهران، ایران

چکیده

هدف:هدف از این پژوهش، تعیین تاثیر یک دوره تمرین مقاومتی برسطوح سرمی GLP-1، DPP-4 و مقاومت انسولین در مردان چاق بود. روش تحقیق: 20 مرد چاق (سن01/2±76/29سال، قد 07/0±79/1متر، وزن 69/5±24/108کیلوگرم، شاخص­توده بدنی 18/1±49/33کیلوگرم بر متر مربع) به­طور تصادفی به 2گروه تمرین مقاومتی و کنترل تقسیم شدند. فعالیت مقاومتی شامل 6ایستگاه با شدت 55-75درصد یک تکرار بیشینه، سه روز در هفته و به مدت 8هفته بود. نمونه­گیری خون در دو مرحله قبل و بعد از 8هفته (48ساعت پس از آخرین جلسه تمرینی) بعد از 12ساعت ناشتایی گرفته شد. داده­ها با استفاده از آزمون آنالیز واریانس در اندازه­گیری مکرر در سطح 05/0P≤ تحلیلشد. یافته­ها:سطوح سرمی GLP-1 گروه تمرین در مقایسه با گروه کنترل به­طور معنادار افزایش یافت(P=0.027). گلوکز خون و سطوح سرمی DPP-4گروه تمرین در مقایسه با گروه کنترل به­طور معنادار کاهش یافت(P=0.019 و P=0.003). اما مقاومت به انسولین گروه تمرین در مقایسه با گروه کنترل تغییر معنادای نداشت(P=0.49). نتیجه‌گیری:احتمالا یک دوره تمرین مقاومتی، باعث افزایش معنادار GLP-1 و کاهش معنادار DPP-4 شده و این تغییرات با کاهش اشتها و تنظیم متابولیسم گلوکز در مردان چاق همراه است، اما احتمالا یا بر مقاومت به انسولین تاثیر معنادار ندارد و یا نیازمند طول مدت بیشتری از تمرین مقاومتی جهت مشاهده تفاوت معنادار در این شاخص می­باشد.

کلیدواژه‌ها

عنوان مقاله [English]

determine the effects of resistance training on serum levels of GLP-1, DPP-4 and insulin resistance in obese men

نویسندگان [English]

  • Asieh Abbassi-Daloii 1
  • Reza Shaghi 1
  • Mozhgan Ahmadi 2
  • Mohammad ali Kohanpour 3

1 Department of Physical Education and Sports Sciences, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran

2 Department of Physical Education and Sports Sciences, Yadegare Emam Branch,Shahre Ray, Islamic Azad University of Tehran, Iran

3 PHD student of biochemistry and sports metabolism, Department of Physical Education and Sports Sciences, Tehran Markaz Branch, Islamic Azad University, Tehran, Iran

چکیده [English]

Objective: The aim of this study was to determine the effects of resistance training on serum levels of GLP-1, DPP-4 and insulin resistance in obese men. Methods: 20 obese men (age 29/76±2/01 years, height 1/79±0/07m, weight 108/24±5/69 kg, BMI 33/49±1/18kg/square meters) divided into resistance training and control groups. The resistance training consisted of 6 stations with 55-75% of one repetition maximum, 3 days a week for 8 weeks. Blood in two phases, before and after 8 weeks (48 hours after the last training session) was collected after 12 hours fasting. Data were analyzed with ANONA repeated measures at P≤0.05. Results: serum levels of GLP-1 training group compared with the group control significantly increased (P=0.027). Glucose and DPP-4 serum levels of training group were significantly decreased compared with the control group (P = 0.019 and P = 0.003). But in training group did not change insulin resistance compared with the control group (P = 0.49). Conclusion: probably Protocol of resistance training due to in a significant increase in GLP-1 and significantly reduced in DPP-4 and these changes is Accompanied with reducing appetite and the regulation of glucose metabolism in obese men, but probably either had no significant effect on insulin resistance or more time of resistance training requires to see a significant difference in the parameter.

کلیدواژه‌ها [English]

  • Insulin resistance
  • resistance exercise
  • glucagon
  • like peptide
  • 1
  • dipeptidyl peptidase
  • 4
  • obesity
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نشریه فیزیولوژی ورزش و فعالیت بدنی
دوره 10، شماره 1 - شماره پیاپی 1
آذر 1396
صفحه 21-30
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سابقه مقاله
  • تاریخ دریافت: 09 اسفند 1394
  • تاریخ بازنگری: 17 خرداد 1402
  • تاریخ پذیرش: 11 دی 1399
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