تاثیر 8 هفته تمرین تناوبی با شدت بالا بر سطح پلاسمایی سلکتین- ای و شاخص‏های گلبول سفید در بیماران قلبی - عروقی

نوع مقاله : علمی - پژوهشی

نویسنده

دانشگاه شهید بهشتی تهران

چکیده

چکیده  هدف: شاخص های التهابی پیشگویی کننده بیماری­های قلبی عروقی نسبت به پروفایل­های لیپیدی در تشخیص این بیماری­ها از دقت بالایی برخوردار هستند. ارائه الگوی تمرینی مناسب جهت کاهش سطح عوامل التهابی در این بیماران از اهمیت بالایی برخوردار است. هدف از پژوهش حاضر، بررسی تاثیر 8 هفته تمرین تناوبی با شدت بالا بر سطح پلاسمایی سلکتین- ای و شاخص‏های گلبول سفید در بیماران قلبی عروقی بود.روش­ شناسی: از بیمارانی که به صورت داوطلبانه برای بازتوانی به بیمارستان قلب شهید رجایی تهران مراجعه کردند، تعداد 20 بیمار قلبی عروقی مرد (50 تا 70 سال) انتخاب شدند و به دو گروه (10n=) تمرین و کنترل تقسیم شدند. بعد از اندازه گیری اوج اکسیژن مصرفی، گروه تمرین به مدت 8 هفته، هر هفته 3 جلسه فعالیت تناوبی شامل 8 تکرار 4 دقیقه­ای (2 دقیقه فعالیت و 2 دقیقه استراحت فعال) اجرا کردند. در حالی که گروه کنترل فعالیت منظمی نداشتند. قبل از شروع و 48 ساعت بعد از آخرین جلسه تمرین در شرایط ناشتایی خون گیری به عمل آمد. برای تجزیه و تحلیل آماری از آزمون T مستقل در سطح معنی داری 05/0 p < استفاده شد.  یافته‏ ها: تجزیه و تحلیل داده­ها کاهش معناداری را در سلکتین- ای (01/0P=) و لنفوسیت ها (01/0P=) نشان داد. اما در پاسخ نوتروفیل ها، مونوسیت­ها و ائوزینوفیل­ها بین دو گروه تفاوت معناداری مشاهده نشد (05/0<P).نتیجه‏ گیری: تمرین تناوبی با شدت بالا باعث کاهش سطح سلکتین- ای در بیماران عروق کرونری ­گردید. احتمالا بخشی از تاثیرات مفید تمرینات تناوبی با شدت در بیماران قلبی عروقی بالا ناشی از سازگاری بدن و در نتیجه کاهش سطح عوامل التهابی و سایتوکاین­هایی باشد که بیشتر از لکوسیت­ها منشا می­گیرند.  

کلیدواژه‌ها


عنوان مقاله [English]

The effect of 8 weeks of high intensity interval training on Plasma E-selectin levels and white blood cells indicators in cardiovascular patients

چکیده [English]

Abstract

aim: cardiovascular disease predictive inflammatory markers are more accurate than lipid profiles in diagnosing diseases. It is important to provide appropriate training pattern in order to reduce the level of inflammatory factors in these patients. The aim of this study was to investigate the effect of 8 weeks of high-intensity interval training on plasma E-selectin levels and white blood cells indices in cardiovascular disease.
Methods:: Among patients who voluntary referred to Shahid Rjaie cardiovascular, medical and research center for cardiac rehabilitation, 20 patients (male, 50-70yr) were selected and randomly divided into two groups (n=10): High intensity interval training and control. After determining the VO2peak, subjects in HIIT group performed an interval protocol included 8 intervals of 2 min activity (running on treadmill) at 90% of VO2peak and 2 min active recovery at 30% of VO2peak, three session per week for 8 weeks. Whereas control group have not regular exercise training. Before the training and 48 hours after the last training session fasting blood samples were taken. Independent t-test at p0.05).

Conclusions: High intensity interval training led to reducing inflammatory factors levels in cardiovascular patients. Probably part of the beneficial effects of high intensity interval training in cardiovascular disease caused by the inflammatory system adaptation and thus reduction the level of inflammatory factors and cytokines with leukocytes origin.

کلیدواژه‌ها [English]

  • cardiac rehabilitation
  • E-selectin
  • High intensity interval training
  • white blood cells
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