تأثیر تمرین مقاومتی بر سطوح سرمی استرادیول، گلوبولین متصل شونده به هورمون جنسی و ترکیب بدن در زنان پیش یائسه دارای اضافه وزن

نوع مقاله : علمی - پژوهشی

نویسندگان

دانشگاه آزاد اسلامی واحد علوم و تحقیقات تهران

چکیده

هدف. چاقی و اضافه وزن با تغییرات گسترده در سطوح هورمون­های جنسی زنان همراه است. از مهمترین هورمون­های جنسی که تغییرات در غلظت آنها با پاتوژنز بیماری­های مختلف مرتبط است می­توان به گلوبولین متصل شونده به هورمون جنسی (SHBG) و استرادیول اشاره کرد. با این همه، نقش تمرینات ورزشی مختلف بر این تغییرات در سطوح هورمون­های جنسی هنوز کاملاً شناخته نشده است. بنابراین، هدف از پژوهش حاضر بررسی تاثیر هشت هفته تمرین مقاومتی منتخب بر سطوح سرمی استرادیول، SHBG و ترکیب بدن در زنان پیش یائسه چاق و دارای اضافه وزن بود. روش­شناسی. بدین منظور، 20 زن پیش یائسه دارای اضافه وزن به دو گروه تجربی (میانگین سنی 11/2 ±3/44 سال) و کنترل (میانگین سنی 37/3±5/42 سال) تقسیم شدند. گروه تجربی به مدت هشت هفته، هر هفته سه جلسه، تمرینات ورزشی مقاومتی با باندهای کشی (ترا باند) را انجام دادند. تمرینات مقاومتی شامل 16 حرکت برای بالاتنه، شکم و پایین تنه بود. هر حرکت با 10 تکرار، 3 ست و 2 دقیقه استراحت بین ست­ها و یک دقیقه استراحت بیت حرکات اجرا شد. داده­ها با آزمون آنالیز کوواریانس تجزیه و تحلیل شد. نتایج: نتایج افزایش معنادار SHBG و کاهش درصد چربی بدن را نشان داد. سطوح سرمی استرادیول در گروه تجربی کاهش یافت که این کاهش از لحاظ آماری معنادار نبود. بحث. بر مبنای نتایج پژوهش حاضر به نظر می­رسد که تمرینات مقاومتی با تراباند اثرات مثبتی بر تعدیل سطوح هورمون­های جنسی زنان دارای اضافه وزن دارد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of eight weeks' selected resistance training on serum levels of estradiol, sex hormone-binding globulin (SHBG) and body composition in obese and overweight premenopausal women

نویسندگان [English]

  • mandana gholami
  • reihaneh tathirimoghaddam
Islamic azad university, science and research branch, Tehran
چکیده [English]

purpose. Obesity and overweight are associated with widespread variations in levels of sex hormones. Among the most important sex hormones that changes in their levels are related to different diseases pathogenesis can mentioned to sex hormone binding globulin (SHBG) and estradiol. However, the effect of different exercise training on this changes in sex hormones levels don’t fully understood yet. Therefore, the aim of present study was to investigate the effect of eight weeks' selected resistance training on serum levels of estradiol, sex hormone-binding globulin (SHBG) and body composition in obese and overweight premenopausal women. Methods. For this purpose, 20 premenopausal women's assigned in two experiment (mean age 44.3±2.11) and control (mean age 42.3±5.37) groups. Experiment group performed resistance training for eight weeks, three sessions in week by using elastic bands (Thera band). Resistance exercise consist of 16 movements for upper body, abdomen and lower body. Each movement performed with 10 repetitions, 3 set and two-minute interval rest between sets and one minute's rest between exercises. Data analyzed by analyze covariance test. Results. Results indicate significant increase in SHBG and decrease body fat percent. Serum levels of estradiol decrease in experiment group but this decrement not significant Statistically. Discussion. According to present study results it seem that resistance training with Thera band have positive effects on modulate sex hormones levels in women with overweight.

کلیدواژه‌ها [English]

  • estrogens
  • elastic band
  • premenopausal
  • breast cancer
Choijookhuu N, Hino SI, Oo PS, Batmunkh B, Hishikawa Y. The role of estrogen receptors in intestinal homeostasis and disease. Receptors & Clinical Investigation. 2016; 4;3(1).
Lopez M, Tena-Sempere M. Estrogens and the control of energy homeostasis: a brain perspective. Trends in Endocrinology & Metabolism. 2015; 26: 411-21.
Bondesson M, Hao R, Lin CY, Williams C, Gustafsson JÅ. Estrogen receptor signaling during vertebrate development. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms. 2015; 1849: 142-51.
Pasquali R. Obesity, fat distribution and infertility. Maturitas. 2006; 54:363-71.
Lorincz AM, Sukumar S. Molecular links between obesity and breast cancer. Endocrine-related cancer. 2006; 13: 279-92.
del Mar Grasa M, Gulfo J, Camps N, Alcala R, Monserrat L, Moreno-Navarrete JM, et al. Modulation of SHBG binding to testosterone and estradiol by sex and morbid obesity. European journal of endocrinology. 2017; 176: 393-404.
McTiernan A, Rajan KB, Tworoger SS, Irwin M, Bernstein L, Baumgartner R, et al. Adiposity and sex hormones in postmenopausal breast cancer survivors. Journal of Clinical Oncology. 2003; 21:1961-6.
Karim R, Mack WJ, Hodis HN, Roy S, Stanczyk FZ. Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women. The Journal of Clinical Endocrinology & Metabolism. 2009; 94: 4136-43.
Leitner L, Jürets A, Itariu BK, Keck M, Prager G, Langer F, et al. Osteopontin promotes aromatase expression and estradiol production in human adipocytes. Breast cancer research and treatment. 2015; 154:63-9.
Ennour-Idrissi K, Maunsell E, Diorio C. Effect of physical activity on sex hormones in women: a systematic review and meta-analysis of randomized controlled trials. Breast Cancer Research. 2015; 17:139.
Rinaldi S, Geay A, Dechaud H, Biessy C, Zeleniuch-Jacquotte A, Akhmedkhanov A, et al. Validity of free testosterone and free estradiol determinations in serum samples from postmenopausal women by theoretical calculations. Cancer Epidemiology and Prevention Biomarkers. 2002; 11:1065-71.
Chan MF, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Khaw KT. Usual physical activity and endogenous sex hormones in postmenopausal women: The European Prospective Investigation into Cancer–Norfolk Population Study. Cancer Epidemiology and Prevention Biomarkers. 2007; 16: 900-5.
McTiernan A, Wu L, Chen C, Chlebowski R, Mossavar‐Rahmani Y, Modugno F, et al. Relation of BMI and physical activity to sex hormones in postmenopausal women. Obesity. 2006; 14:1662-77.
Baglietto L, English DR, Hopper JL, MacInnis RJ, Morris HA, Tilley WD, Krishnan K, Giles GG. Circulating steroid hormone concentrations in postmenopausal women in relation to body size and composition. Breast cancer research and treatment. 2009; 115:171-9.
Friedenreich CM, Neilson HK, Wang Q, Stanczyk FZ, Yasui Y, Duha A, et al. Effects of exercise dose on endogenous estrogens in postmenopausal women: a randomized trial. Endocrine-related cancer. 2015; 22: 863-76.
Dethlefsen C, Lillelund C, Midtgaard J, Andersen C, Pedersen BK, Christensen JF, Hojman P. Exercise regulates breast cancer cell viability: systemic training adaptations versus acute exercise responses. Breast cancer research and treatment. 2016; 159:469-79.
Friedenreich CM, Woolcott CG, McTiernan A, Ballard-Barbash R, Brant RF, Stanczyk FZ, et al. Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. Journal of Clinical Oncology. 2010; 28:1458-66.
Yu W, An C, Kang H. Effects of resistance exercise using thera-band on balance of elderly adults: a randomized controlled trial. Journal of physical therapy science. 2013; 25:1471-3.
Patterson RM, Stegink Jansen CW, Hogan HA, Nassif MD. Material properties of thera-band tubing. Physical therapy. 2001; 81:1437-45.
Kwon HR, Han KA, Ku YH, Ahn HJ, Koo BK, Kim HC, et al. The effects of resistance training on muscle and body fat mass and muscle strength in type 2 diabetic women. Korean diabetes journal. 2010; 34:101-10.
Thiebaud RS, Loenneke JP, Fahs CA, Rossow LM, Kim D, Abe T, Anderson MA, Young KC, Bemben DA, Bemben MG. The effects of elastic band resistance training combined with blood flow restriction on strength, total bone‐free lean body mass and muscle thickness in postmenopausal women. Clinical physiology and functional imaging. 2013; 33:344-52.
Lamar CA, Dorgan JF, Longcope C, Stanczyk FZ, Falk RT, Stephenson HE. Serum sex hormones and breast cancer risk factors in postmenopausal women. Cancer Epidemiology and Prevention Biomarkers. 2003; 12: 380-3.
Friedenreich CM, Orenstein MR. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. The Journal of nutrition. 2002; 132:3456S-64S.
Clemons M, Goss P. Estrogen and the risk of breast cancer. New England Journal of Medicine. 2001; 344:276-85.
Key T, Appleby P, Barnes I, Reeves G. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. Journal of the National Cancer Institute. 2002; 94:606-16.
Friedenreich CM. Physical activity and breast cancer risk: the effect of menopausal status. Exercise and sport sciences reviews. 2004; 32:180-4.
Consitt LA, Copeland JL, Tremblay MS. Endogenous anabolic hormone responses to endurance versus resistance exercise and training in women. Sports Medicine. 2002; 32:1-22.
Roberts CK, Croymans DM, Aziz N, Butch AW, Lee CC. Resistance training increases SHBG in overweight/obese, young men. Metabolism. 2013; 62:725-33.
Häkkinen K, Pakarinen A, Kyröläinen H, Cheng S, Kim DH, Komi PV. Neuromuscular adaptations and serum hormones in females during prolonged power training. International Journal of Sports Medicine. 1990; 11:91-8.
Lee JS, LaCroix AZ, Wu L, Cauley JA, Jackson RD, Kooperberg C, et al. Associations of serum sex hormone-binding globulin and sex hormone concentrations with hip fracture risk in postmenopausal women. The Journal of Clinical Endocrinology & Metabolism. 2008; 93: 1796-803.
Kim C, Pi-Sunyer X, Barrett-Connor E, Stentz FB, Murphy MB, Kong S, et al. Diabetes Prevention Program Research Group. Sex hormone binding globulin and sex steroids among premenopausal women in the diabetes prevention program. The Journal of Clinical Endocrinology & Metabolism. 2013; 98:3049-57.
Wang F, Vihma V, Soronen J, Turpeinen U, Hämäläinen E, Savolainen-Peltonen H, et al. 17β-estradiol and estradiol fatty acyl esters and estrogen-converting enzyme expression in adipose tissue in obese men and women. The Journal of Clinical Endocrinology & Metabolism. 2013; 98:4923-31.
Monninkhof EM, Velthuis MJ, Peeters PH, Twisk JW, Schuit AJ. Effect of exercise on postmenopausal sex hormone levels and role of body fat: a randomized controlled trial. Journal of clinical oncology. 2009; 27: 4492-9.
Figueroa A, Going SB, Milliken LA, Blew RM, Sharp S, Teixeira PJ, Lohman TG. Effects of exercise training and hormone replacement therapy on lean and fat mass in postmenopausal women. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2003; 58:266-70.
Smith AJ, Phipps WR, Arikawa AY, O'Dougherty M, Kaufman B, Thomas W, et al. Effects of aerobic exercise on premenopausal sex hormone levels: results of the WISER study, a randomized clinical trial in healthy, sedentary, eumenorrheic women. Cancer Epidemiology and Prevention Biomarkers. 2011; 1098-1107.
Kraemer WJ, Ratamess NA. Hormonal responses and adaptations to resistance exercise and training. Sports medicine. 2005; 35:339-61.