نوع مقاله : علمی - پژوهشی
نویسندگان
گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه سمنان، سمنان، ایران
چکیده
هدف: با توجه به تأثیرات مثبت فعالیت بدنی در بیماران مبتلا به مولتیپل اسکلروزیس )ام.اس( و نقش اینترلوکین 17
IL-17( ( در فرآیند دمیلینه شدن سلول های عصبی، هدف از این پژوهش، بررسی اثر تمرین یوگا، بر سطوح سرمی ،IL-17
درصد چربی بدن و قدرت عضلانی زنان مبتلا به ام.اس است.
روش ها: به این منظور، تعداد 16 زن مبتلا به ام.اس )میانگین سن 7/ 7± 8/ 37 سال، قد 4/ 7± 7/ 161 سانتیمتر و وزن
70/7±18/2 کیلوگرم( با 4EDSS > انتخاب و به طور تصادفی، به دو گروه تمرینی یوگا ) n=8 ( و کنترل ) n=8 ( تقسیم
شدند. گروه تجربی، به مدت 8 هفته ) 3 جلسه در هفته(، در جلسات تمرین یوگا شرکت کرده و گروه کنترل، فعالیت
معمول روزانه خود را ادامه داد. نمونههای خونی، 48 ساعت قبل و 48 ساعت پس از دوره تمرین جمع آوری شد و برای
ارزیابی سطوح سرمی IL-17 ، از کیتهای الایزا استفاده شد. اندازه گیری درصد چربی بدن، از روش بیوالکتریکال ایمپدانس
و با دستگاه تحلیل گر ترکیب بدن و قدرت عضلانی با استفاده از نیروسنج دیجیتالی انجام شد. تجزیه و تحلیل آماری
دادهها، از طریق آزمون t مستقل، در سطح معنی داری 05 / p≤0 و با استفاده از نرمافزار SPSS 22 انجام گرفت.
نتایج: دادهها نشان داد که سطح IL-17 در گروه تجربی، پس از 8 هفته تمرین، کمتر از پیشآزمون بود ) 001 / ،)p=0
ولی تغییرات در گروه کنترل، معنی دار ) 825 / p=0 ( نبود. میزان قدرت عضلانی، در گروه تجربی در پسآزمون، نسبت به
پیشآزمون افزایش یافت ) 002 / p=0 (. در میزان درصد چربی بدن آزمودنیها، تغییر معنی داری مشاهده نشد ) 513 / .)p=0
نتیجه گیری: بر اساس نتایج این پژوهش، هشت هفته تمرین یوگا، ممکن است از طریق کاهش سطوح سرمی ،IL-17
نقش مهمی در کمک به بهبود وضعیت بیماران مبتلا به ام.اس داشته باشد.
کلیدواژه‌ها
عنوان مقاله [English]
The effects of eight weeks’ yoga training on serum levels of IL-17 in women with multiple sclerosis
نویسندگان [English]
- Seyed Mohsen Avandi
- Marjaneh Zahedi
Sport Science Department, Human Faculty, Semnan University, Semnan, Iran
چکیده [English]
Purpose: The nicotine derived nitrosamine ketone (NNK) is one of the strongest carcinogens in tobacco that involved in induction of lung cancer by changing the stimulation of tumor associated macrophages. The aim of this study was to effect of swimming training and exposure to nicotine derived nitrosamine ketone (NNK) on the immunohistochemical response of tumor-associated macrophages in wistar rats.
Methods: For this purpose, 46 Wistar rats were randomly divided into five groups consist of training, training + NNK, NNK, saline and control. NNK-induced groups received NNK subcutaneously one day per week at a rate of 12/5 mg per kg body weight and the training groups performed submaximal swimming training for 12 weeks. Levels of CD68-Tumor associated macrophages in homogenized lung tissue were measured by immunohistochemistry. To analyze the data; ANOVA and tukey’s test were used at a significance level of p≤0.05.
Results: The results showed that immunohistochemical expression of TAM in the training group was significantly lower than the NNK group (P = 0.001) (92%). Immunohistochemical expression of TAM was also significantly lower in the NNK + training group than in the NNK group (P = 0.001) (92%). In addition, the immunohistochemical expression of TAM in the NNK group was significantly higher than the solvent group (P = 0.001) (766%).
Conclusion: Generally, it could be confirmed that regular submaximal swimming training plays an important role in inhibition of the effects of lung inflammation induced by NNK via decreased of Tumor associated macrophages activity.
کلیدواژه‌ها [English]
- Cytokines
- Inflammation
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